Nature Search

Hydrogen bonding and biological specificity analysed by protein engineering

Alan R. Fersht
Jian-Ping Shi
Greg Winter
Research21 Mar 1985
Nature

Volume: 314, P: 235-238
Inhibition of Tumour Cell Viability by DNA

J. LESLIE GLICK
ANTHONY P. SALIM
Research18 Feb 1967
Nature

Volume: 213, P: 676-678
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Qualitative Aspects of the Chemistry and Biology of Radiomimetic (Mutagenic) Substances

ANTHONY LOVELESS
Research03 Mar 1951
Nature

Volume: 167, P: 338-342
A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone

Károly Nikolics
Anthony J. Mason
Peter H. Seeburg
Research01 Aug 1985
Nature

Volume: 316, P: 511-517
Targeting SUMOylation promotes cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma

Synovial sarcoma (SS) is a difficult-to-treat cancer, driven by the fusion oncoprotein SS18::SSX. SS18::SSX alters the BAF (mammalian SWI/SNF) chromatin remodelling complex to create an oncogenic transcriptome. Here, the authors identify SS18::SSX-driven SMARCE1 SUMOylation as a therapeutic vulnerability in SS and show that SUMOylation inhibition stabilizes the cBAF complex, inducing cell death and sensitization of SS to chemotherapy.

Konstantinos V. Floros
Carter K. Fairchild Jr.
Anthony C. Faber
ResearchOpen Access05 Nov 2025
Nature Communications

Volume: 16, P: 1-26
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
The triple QSO PG1115 + 08: another probable gravitational lens

Ray J. Weymann
David Latham
J. Anthony Tyson
Research26 Jun 1980
Nature

Volume: 285, P: 641-643
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
N–Methyl–D–aspartate antagonists limit aminoglycoside antibiotic–induced hearing loss

Anthony S. Basile
Jer-Min Huang
Phil Skolnick
Research01 Dec 1996
Nature Medicine

Volume: 2, P: 1338-1343
A large increase in enzyme–substrate affinity by protein engineering

Anthony J. Wilkinson
Alan R. Fersht
Greg Winter
Research12 Jan 1984
Nature

Volume: 307, P: 187-188
Population dynamics of fox rabies in Europe

Roy M. Anderson
Helen C. Jackson
Anthony M. Smith
Research26 Feb 1981
Nature

Volume: 289, P: 765-771
Lack of M-MuSV tumour regression associated with T lymphocyte tolerance

Luigi Chieco-Bianchi
Dino Collavo
Anthony J. S. Davies
Research26 Jun 1980
Nature

Volume: 285, P: 667-668
Characterizing trachoma elimination using serology

The study advances the use of serological surveys to guide trachoma elimination program decisions and provides a way to set thresholds for whether or not to continue an intervention program.

Everlyn Kamau
Pearl Anne Ante-Testard
Benjamin F. Arnold
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Dream Deprivation: an Experimental Reappraisal

ANTHONY KALES
FREDERICK S. HOEDEMAKER
EDWARD L. LICHTENSTEIN
Research26 Dec 1964
Nature

Volume: 204, P: 1337-1338
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

Scott Koenig
Anthony J. Conley
H. Clifford Lane
Research01 Apr 1995
Nature Medicine

Volume: 1, P: 330-336
Off-the-shelf proteins that rival tailor-made antibodies as catalysts

Florian Hollfelder
Anthony J. Kirby
Dan S. Tawfik
Research05 Sept 1996
Nature

Volume: 383, P: 60-63
A threading receptor for polysaccharides

A synthetic receptor has been designed to form pseudorotaxanes and polypseudorotaxanes with oligo/polysaccharides in water. Target substrates have all-equatorial substitution patterns, and include cellulose, cellodextrins and the cationic polysaccharide chitosan. The results suggest an approach to dissolving these polysaccharides under mild conditions and could prove useful for processing these abundant renewable resources.

Tiddo J. Mooibroek
Juan M. Casas-Solvas
Anthony P. Davis
Research23 Nov 2015
Nature Chemistry

Volume: 8, P: 69-74
In the eye of the beholder

J. Anthony Movshon
Books & Arts02 May 1991
Nature

Volume: 351, P: 24
Accurate whole human genome sequencing using reversible terminator chemistry

David R. Bentley
Shankar Balasubramanian
Anthony J. Smith
ResearchOpen Access06 Nov 2008
Nature

Volume: 456, P: 53-59
A new locus for autosomal dominant retinitis pigmentosa on chromosome 7p

Chris F. Inglehearn
Simon A. Carter
Shomi S. Bhattacharya
Research01 May 1993
Nature Genetics

Volume: 4, P: 51-53
Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

Kevin W. Ng
Jesse Boumelha
George Kassiotis
Amendments and CorrectionsOpen Access14 Jan 2026
Nature

Volume: 649, P: 1330
Sources of sedimentary lipids deduced from stable carbon-isotope analyses of individual compounds

Gareth Rieley
Robert J. Collier
Anthony E. Fallick
Research01 Aug 1991
Nature

Volume: 352, P: 425-427
Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

Ronald M. Lindsay
Anthony J. Harmar
Research26 Jan 1989
Nature

Volume: 337, P: 362-364
A gene for Hirschsprung disease (megacolon) in the pericentromeric region of human chromosome 10

Misha Angrist
Erick Kauffman
Aravinda Chakravarti
Research01 Aug 1993
Nature Genetics

Volume: 4, P: 351-356
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Erratum: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

Marcia L. Moss
S.-L. Catherine Jin
J. David Becherer
Amendments and Corrections17 Apr 1997
Nature

Volume: 386, P: 738
An image of the Sunyaev–Zel'dovich effect

Michael Jones
Richard Saunders
Donald Wilson
Research23 Sept 1993
Nature

Volume: 365, P: 320-323
The Metabolism of Free Fatty Acids and Triacylglycerols by the Fetal Liver in a Guinea Pig Model of Intrauterine Growth Retardation

Ann Detmer
Anthony M Carter
Chris R Thomas
Research01 Oct 1992
Pediatric Research

Volume: 32, P: 441-446
In utero rearrangements in the trithorax-related oncogene in infant leukaemias

Anthony M. Ford
Susan A. Ridge
Mel Greaves
Research27 May 1993
Nature

Volume: 363, P: 358-360
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Increased ¹²⁵I-Insulin Receptor Binding to Erythrocytes of Hypoglycemic Infants and Children

George P Chrousos
Helena Wachlicht-Rodbard
Marvin Cornblath
Research01 Oct 1981
Pediatric Research

Volume: 15, P: 1345-1347
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Lung adenocarcinoma promotion by air pollutants

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

William Hill
Emilia L. Lim
Charles Swanton
Research05 Apr 2023
Nature

Volume: 616, P: 159-167
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Over 170 susceptibility loci have been identified by genome-wide association studies in breast cancer. Here, the authors interrogated the role of risk-associated variants from non-breast tissue, and using expression quantitative trait loci, identify potential target genes of known breast cancer susceptibility variants, as well as 11 regions not previously known to be associated with breast cancer risk.

Manuel A. Ferreira
Eric R. Gamazon
Georgia Chenevix-Trench
ResearchOpen Access15 Apr 2019
Nature Communications

Volume: 10, P: 1-18
Competition for cellular factors that activate metallothionein gene transcription

Carl Séguin
Barbara K. Felber
Dean H. Hamer
Research20 Dec 1984
Nature

Volume: 312, P: 781-785
A second serine protease associated with mannan-binding lectin that activates complement

Steffen Thiel
Thomas Vorup-Jensen
Jens C. Jensenius
Research03 Apr 1997
Nature

Volume: 386, P: 506-510
Observation of quantum entanglement with top quarks at the ATLAS detector

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s = 13 TeV and an integrated luminosity of 140 fb⁻¹.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access18 Sept 2024
Nature

Volume: 633, P: 542-547
3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

Ependymoma is a tumor of the brain or spinal cord with the two most common and aggressive types mainly occurring in children. Here the authors employ 3D genomics and epigenomics to reveal targets for aggressive ependymoma tumors in children.

Konstantin Okonechnikov
Aylin Camgöz
Lukas Chavez
ResearchOpen Access21 Apr 2023
Nature Communications

Volume: 14, P: 1-16
Monitoring transmission intensity of trachoma with serology

Trachoma is targeted for global elimination as a public health problem by 2030. Here, the authors combine data from 14 African populations to show that IgG in children is a robust approach to monitor transmission as populations approach elimination.

Christine Tedijanto
Anthony W. Solomon
Benjamin F. Arnold
ResearchOpen Access05 Jun 2023
Nature Communications

Volume: 14, P: 1-12
Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates

Radiation and steroid dosing can affect the immune composition of brain metastasis (BM). The authors have designed a pilot study of pre-operative stereotactic radiosurgery with low or high dose of peri-operative dexamethasone for resectable brain metastases, here reporting clinical outcomes and characterization of intratumor TCF1+ CD8+ stem-like T cell immune niches in the brain.

Caroline S. Jansen
Meghana S. Pagadala
Zachary S. Buchwald
ResearchOpen Access14 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Acute SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the respiratory pathogen that caused the coronavirus disease 2019 (COVID-19) pandemic. In this Primer, Sherman et al. focus on the acute stage of SARS-CoV-2 infection, describing its epidemiology and pathogenesis, discussing its diagnosis and management, and summarizing effects on quality of life as well as areas for further research.

Amy C. Sherman
Glenda E. Gray
Lindsey R. Baden
Reviews24 Oct 2025
Nature Reviews Disease Primers

Volume: 11, P: 1-17
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
A biomimetic receptor for glucose

Synthetic receptors can be used to help understand biological systems, but rarely compete in terms of affinity or selectivity. Now, a glucose-binding compound has been prepared that, despite its symmetry and simplicity, can match all but the strongest glucose-binding proteins. The high binding affinity and outstanding selectivity of this receptor may translate into biomedical applications.

Robert A. Tromans
Tom S. Carter
Anthony P. Davis
Research12 Nov 2018
Nature Chemistry

Volume: 11, P: 52-56
Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence

Enterococcus faecalis-derived adenine increases enterohaemorrhagic Escherichia coli virulence by relieving Hha-dependent repression of Type 3 Secretion System activity.

Fernando H. Martins
Thibaut Rosay
Vanessa Sperandio
Research04 Jul 2024
Nature Microbiology

Volume: 9, P: 2448-2461
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

A transcriptome-wide association study identifies associations of genetically predicted gene expression with breast cancer risk. This analysis finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci.

Lang Wu
Wei Shi
Wei Zheng
Research18 Jun 2018
Nature Genetics

Volume: 50, P: 968-978
The DNA sequence of the human X chromosome

Mark T. Ross
Darren V. Grafham
David R. Bentley
Research17 Mar 2005
Nature

Volume: 434, P: 325-337
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18

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