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Showing 1–3 of 3 results
Advanced filters: Author: Anthony R. Prudden Clear advanced filters

  • Preparation of well-defined N-glycans is very demanding, which hampers progress in glycoscience. Now, a biomimetic synthetic approach has been developed in which a readily available bi-antennary glycan can be converted in ten or fewer steps into multi-antennary N-glycans. This approach enables each arm to be uniquely extended by glycosyltransferases to give complex branched N-glycans.

    • Lin Liu
    • Anthony R. Prudden
    • Geert-Jan Boons
    Research
    Nature Chemistry
    Volume: 11, P: 161-169

  • The structure, molecular and mechanistic details of the human α1,3-fucosyltransferase FUT9 provide insight into the synthesis of diverse and modified glycan-capping Lewis antigen structures by a conserved family of mammalian fucosyltransferases.

    • Renuka Kadirvelraj
    • Bhargavi M. Boruah
    • Kelley W. Moremen
    Research
    Nature Chemical Biology
    Volume: 19, P: 1022-1030

  • A class of enzymes known as alkyltransferase-like proteins (ATLs) can protect against alkylation damage to DNA. To gain insight into how this occurs, the structure of a yeast ATL has been solved in the presence and absence of damaged DNA, revealing that ATL flips the alkylated base out of the DNA helix, leaving the lesion to be acted on by proteins of the nucleotide excision repair pathway.

    • Julie L. Tubbs
    • Vitaly Latypov
    • John A. Tainer
    Research
    Nature
    Volume: 459, P: 808-813