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Showing 1–5 of 5 results
Advanced filters: Author: Anthony T. Tubbs Clear advanced filters

  • A class of enzymes known as alkyltransferase-like proteins (ATLs) can protect against alkylation damage to DNA. To gain insight into how this occurs, the structure of a yeast ATL has been solved in the presence and absence of damaged DNA, revealing that ATL flips the alkylated base out of the DNA helix, leaving the lesion to be acted on by proteins of the nucleotide excision repair pathway.

    • Julie L. Tubbs
    • Vitaly Latypov
    • John A. Tainer
    Research
    Nature
    Volume: 459, P: 808-813

  • In cells with microsatellite instability, expanded TA-dinucleotide repeats form cruciform structures that stall replication forks and cause chromosome shattering in the absence of the WRN helicase.

    • Niek van Wietmarschen
    • Sriram Sridharan
    • André Nussenzweig
    Research
    Nature
    Volume: 586, P: 292-298

  • The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.

    • Xia Ding
    • Arnab Ray Chaudhuri
    • Shyam K. Sharan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Antigen receptor loci contain numerous gene segments that are recombined in response to antigen stimulation. The RAG endonuclease makes the double-strand breaks that initiate recombination. The ends of these breaks are hairpins that can only be cleaved by the Artemis nuclease. Here, it is shown that the specificity for Artemis is dictated by the histone protein H2AX, in cooperation with the repair protein MDC-1. In the absence of H2AX, another nuclease, CtIP, can open the ends but they are not joined efficiently; this leads to genomic instability.

    • Beth A. Helmink
    • Anthony T. Tubbs
    • Barry P. Sleckman
    Research
    Nature
    Volume: 469, P: 245-249