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Showing 1–5 of 5 results
Advanced filters: Author: Antje K. Huebner Clear advanced filters
  • The regulatory role of calcitonin in bone homeostasis is well studied, yet its molecular activity is poorly understood. The authors show that calcitonin regulates bone cells function by inhibiting the osteoclast secretion of sphingosine 1-phosphate, a lipid mediator of osteoclast–osteoblast crosstalk.

    • Johannes Keller
    • Philip Catala-Lehnen
    • Michael Amling
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-13
  • Proper calcium levels are needed to maintain healthy bones. Michael Amling and his colleagues now show that gastric acidification is a key part of in this process. These findings have possible important clinical implications for patients with osteoporosis and/or those on proton-pump inhibitors, as well as those with a rare genetic disease that causes excess bone mass.

    • Thorsten Schinke
    • Arndt F Schilling
    • Michael Amling
    Research
    Nature Medicine
    Volume: 15, P: 674-681
  • The protein FAM134B is an endoplasmic reticulum (ER)-resident receptor that facilitates ER autophagy, and downregulation of this protein (mutations of which are also known to cause sensory neuropathy in humans) results in expanded ER structures and degeneration of mouse sensory neurons.

    • Aliaksandr Khaminets
    • Theresa Heinrich
    • Ivan Dikic
    Research
    Nature
    Volume: 522, P: 354-358
  • Phaeochromocytomas and paragangliomas (PPGL) are rare endocrine tumours that can affect paediatric patients as well as adults. In this first international Consensus Statement on PPGL in paediatric patients, the authors discuss the diagnosis, management and long-term surveillance of these tumours in children and adolescents.

    • Ruth T. Casey
    • Emile Hendriks
    • Christina Pamporaki
    Reviews
    Nature Reviews Endocrinology
    Volume: 20, P: 729-748