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Showing 1–6 of 6 results
Advanced filters: Author: Antoine Cléry Clear advanced filters

  • SRSF1 is an oncoprotein that plays important roles in RNA metabolism. We reveal the structure of the human SRSF1 RRM1 bound to RNA, and propose a bimodal mode of interaction of the protein with RNA. A single mutation in RRM1 changed SRSF1 specificity for RNA and made it active on SMN2 exon7 splicing.

    • Antoine Cléry
    • Miroslav Krepl
    • Frédéric H.-T. Allain
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Alternative splicing, critical for gene expression, is deregulated in many diseases. Here the authors develop decoy oligonucleotides to specifically downregulate splicing factors activity.

    • Polina Denichenko
    • Maxim Mogilevsky
    • Rotem Karni
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • NMR-based structural analysis of the RNA duplex formed by SMN2 exon 7 and U1 snRNA reveals that the splicing modifier SMN-C5 pulls the bulged adenine into the RNA helix base stack and transforms the weak 5ʹ splice site of SMN2 exon 7 into a stronger one.

    • Sébastien Campagne
    • Sarah Boigner
    • Frédéric H.-T. Allain
    Research
    Nature Chemical Biology
    Volume: 15, P: 1191-1198

  • Tra2-β1 is a splicing factor involved in facilitating SMN2 exon 7 splicing. Exon 7 inclusion prevents SMN2 from rescuing the SMN1 deletion, a situation linked to spinal muscular atrophy. The structure of Tra2-β1 in complex with an RNA target is now presented, giving insight into purine recognition by an unusual RNA binding mode.

    • Antoine Cléry
    • Sandrine Jayne
    • Frédéric H-T Allain
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 443-450

  • Small molecules correcting the splicing deficit of the survival of motor neuron 2 (SMN2) gene have been identified as having therapeutic potential. Here, the authors provide evidence that SMN2 mRNA forms a ribonucleoprotein complex that can be specifically targeted by these small molecules.

    • Manaswini Sivaramakrishnan
    • Kathleen D. McCarthy
    • Friedrich Metzger
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13