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Enhancing neuronal chloride extrusion rescues α2/α3 GABA_A-mediated analgesia in neuropathic pain

Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABA_A receptor in a neuropathic pain model, inhibition eventually fails due to KCC2 hypofunction.

Louis-Etienne Lorenzo
Antoine G. Godin
Yves De Koninck
ResearchOpen Access13 Feb 2020
Nature Communications

Volume: 11, P: 1-23
A travelling-wave strategy for plant–fungal trade

Symbiotic fungi control network-level structure and flows to meet trade demands.

Loreto Oyarte Galvez
Corentin Bisot
Thomas S. Shimizu
ResearchOpen Access26 Feb 2025
Nature

Volume: 639, P: 172-180
Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization

Inhibition in spinal nociceptive pathways is weaker and more labile in lamina I —where thermal input is primarily processed— than in lamina II that encodes predominantly high threshold mechanical input. This explains why noxious thermal input makes spinal circuits prone to catastrophic sensitization.

Francesco Ferrini
Jimena Perez-Sanchez
Yves De Koninck
ResearchOpen Access07 Aug 2020
Nature Communications

Volume: 11, P: 1-18
Enhancing KCC2 function counteracts morphine-induced hyperalgesia

Francesco Ferrini
Louis-Etienne Lorenzo
Yves De Koninck
ResearchOpen Access20 Jun 2017
Scientific Reports

Volume: 7, P: 1-8
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

Measurements of subclonal expansion of ctDNA in the plasma before surgery may enable the prediction of future metastatic subclones, offering the possibility for early intervention in patients with non-small-cell lung cancer.

Christopher Abbosh
Alexander M. Frankell
Charles Swanton
Research13 Apr 2023
Nature

Volume: 616, P: 553-562
Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain

A super-resolution imaging technique based on single-nanotube tracking is used to study the nanoscale organization and local viscosity of the brain extracellular space.

Antoine G. Godin
Juan A. Varela
Laurent Cognet
Research21 Nov 2016
Nature Nanotechnology

Volume: 12, P: 238-243
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis

Treatment of pain with morphine leads to paradoxical hyperalgesia. The authors provide evidence that morphine-induced hyperalgesia is a result of downregulation of the chloride transporter KCC2 in spinal lamina I neurons. Microglial expression of P2X4 receptors and release of BDNF may underlie this change in neuronal chloride homeostasis and morphine-induced hyperalgesia.

Francesco Ferrini
Tuan Trang
Yves De Koninck
Research06 Jan 2013
Nature Neuroscience

Volume: 16, P: 183-192
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Polygenic risk scores for severe psychiatric disorders in bipolar disorders: associations with the clinical and dimensional expression, interactions with childhood maltreatment and mediation models

Bruno Etain
Mohamed Lajnef
LM Vayssié
ResearchOpen Access25 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-9
Reply to The small molecule CLP257 does not modify activity of the K⁺–Cl⁻ co-transporter KCC2 but does potentiate GABA_A receptor activity

Martin Gagnon
Marc J Bergeron
Yves De Koninck
Correspondence07 Dec 2017
Nature Medicine

Volume: 23, P: 1396-1398
Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1

Luana Spano
Cynthia Marie-Claire
Bruno Etain
ResearchOpen Access01 Mar 2024
Translational Psychiatry

Volume: 14, P: 1-7
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI)

Adrien Joseph
Stéphanie Moriceau
Guido Kroemer
ResearchOpen Access06 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-10

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