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Showing 1–4 of 4 results
Advanced filters: Author: Antoine Tabarin Clear advanced filters

  • Adrenocortical carcinomas (ACC) are aggressive and often resistant to therapy. Here, the authors provide a single-nucleus transcriptomic atlas of ACCs and normal adrenal glands, finding ecotypes in steroid and microenvironment cells that are associated with clinical outcomes.

    • Anne Jouinot
    • Yoann Martin
    • Guillaume Assié
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Systematic screening studies, performed mainly in patients with diabetes mellitus, have revealed an unexpectedly high prevalence of occult Cushing syndrome. However, a screening strategy is only justified if it is supported by enough evidence of its efficacy and if benefits will outweigh drawbacks. The authors review currently available systematic screening studies for occult Cushing syndrome and assess the indications for and against screening for this condition.

    • Antoine Tabarin
    • Paul Perez
    Reviews
    Nature Reviews Endocrinology
    Volume: 7, P: 445-455

  • Jérôme Bertherat, Aurélien de Reyniès and colleagues perform integrated genomic analyses of adrenocortical carcinomas. They discover recurrent alterations in several new driver genes, including ZNRF3, DAXX, TERT and MED12, and identify two distinct molecular subgroups with opposite clinical outcomes.

    • Guillaume Assié
    • Eric Letouzé
    • Jérôme Bertherat
    Research
    Nature Genetics
    Volume: 46, P: 607-612