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Showing 1–4 of 4 results
Advanced filters: Author: Antoinette van Weverwijk Clear advanced filters

  • Cancer cells must develop distinct metabolic adaptations to survive in challenging metastatic environments. Here, the authors find, via an in vivo RNAi screen, that the aldo-keto reductase AKR1B10 limits the toxic side effects of oxidative stress to sustain fatty acid oxidation and promote metastatic colonisation.

    • Antoinette van Weverwijk
    • Nikolaos Koundouros
    • Clare M. Isacke
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.

    • Ute Jungwirth
    • Antoinette van Weverwijk
    • Clare M. Isacke
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • This Review outlines how the profound intertumoural heterogeneity in immune landscapes of tumours is shaped by cancer cell-intrinsic alterations and highlights how the crosstalk between these two continuously evolving systems not only challenges therapy success of immunomodulatory drugs but also provides the basis for new therapeutic strategies to overcome immune evasion.

    • Antoinette van Weverwijk
    • Karin E. de Visser
    Reviews
    Nature Reviews Cancer
    Volume: 23, P: 193-215