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Showing 1–4 of 4 results
Advanced filters: Author: Anton Petcherski Clear advanced filters

  • In NAFLD, high levels of fatty acids in the liver impair lysosomal acidification. Here, the authors report the synthesis of novel biodegradable acid-activated acidifying nanoparticles that re-acidify lysosomes, restore autophagy, and reverse fasting hyperglycemia and hepatic steatosis in fat mice.

    • Jialiu Zeng
    • Rebeca Acin-Perez
    • Mark W. Grinstaff
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • A study describing an approach that combines imaging and profiling techniques to structurally and functionally analyse lung cancer in vivo, revealing heterogeneous mitochondrial networks and an association between bioenergetic phenotypes and mitochondrial organization and function.

    • Mingqi Han
    • Eric A. Bushong
    • David B. Shackelford
    ResearchOpen Access
    Nature
    Volume: 615, P: 712-719

  • Electron transport chain (ETC) regulation can have important consequences for cellular bioenergetics. Here, Acín-Pérez et al. show that macrophage ETC regulation by the Fgr kinase can also affect systemic metabolism in the setting of diet-induced obesity.

    • Rebeca Acín-Pérez
    • Salvador Iborra
    • José Antonio Enríquez
    Research
    Nature Metabolism
    Volume: 2, P: 974-988

  • A systems-wide study of mice infected with SARS-CoV2 under ketogenic diet shows that this diet reprograms the transcriptional and metabolic response in animals following infection with improved health, reduced inflammation, and restored metabolism.

    • Amelia Palermo
    • Shen Li
    • Arjun Deb
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-15