Human serum transferrin plays a crucial role in iron homeostasis, but its interaction with potential metallodrugs remains underexplored. Here, the authors solve the X-ray structure of an adduct between transferrin (FeC-hTF) and [VV2O6]2–, generated from a vanadium-based drug [VIVO(acac)2], showing that binding preserves the overall conformation of FeC-hTF.
- Anne-Sophie Banneville
- Rosanna Lucignano
- Antonello Merlino
