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Advanced filters: Author: Antonette Bennett Clear advanced filters

  • Adeno-associated viruses (AAVs) have emerged as promising gene therapy vectors.The AAV capsid consists of 60 subunits made up from three distinct viral proteins (VPs). Here authors record high-resolution native mass spectra of intact AAV capsids to assess the VP stoichiometries in a panel of serotypes and reveals an extremely heterogeneous population of capsids of variable composition.

    • Tobias P. Wörner
    • Antonette Bennett
    • Albert J. R. Heck
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9