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Showing 1–5 of 5 results
Advanced filters: Author: Antonina V. Kurtova Clear advanced filters

  • Using human bladder cancer xenograft models, a new mechanism involving an active proliferative response of cancer stem cells to chemotherapy-induced damage is shown, driven by prostaglandin E2 (PGE2) release in a manner similar to PGE2-induced wound repair; pharmacological inhibition of the PGE2/COX2 axis by celecoxib attenuates chemoresistance, suggesting a possible adjunctive therapy for bladder carcinomas.

    • Antonina V. Kurtova
    • Jing Xiao
    • Keith Syson Chan
    Research
    Nature
    Volume: 517, P: 209-213

  • In this Review, Ho et al. discuss historical perspectives and recent progress in the study of normal urothelial and neoplastic bladder stem cells. In particular, they focus on developments in stem cell isolation, molecular characterization, and global gene expression profiling.

    • Philip Levy Ho
    • Antonina Kurtova
    • Keith Syson Chan
    Reviews
    Nature Reviews Urology
    Volume: 9, P: 583-594

  • Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating  these collagen III/CD167a-driven metastatic foci.

    • Yu-Cheng Lee
    • Antonina V. Kurtova
    • Keith Syson Chan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Hoeck et al. show that disruption of the hair follicle stem cell compartment by loss of Lgr5+ stem cells is followed by an inflammatory response and CD34+ stem cell activation and proliferation, to eventually replenish the Lgr5+ population.

    • Joerg D. Hoeck
    • Brian Biehs
    • Frederic J. de Sauvage
    Research
    Nature Cell Biology
    Volume: 19, P: 666-676