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Showing 1–3 of 3 results
Advanced filters: Author: Antonio Angelastro Clear advanced filters

  • Aldehyde-bearing proteins are shown to be suitable substrates for Horner–Wadsworth–Emmons reactions. Applying this process to proteins and glycoproteins enables site-specific bioconjugation with tunable reaction kinetics.

    • Antonio Angelastro
    • Alexey Barkhanskiy
    • Sabine L. Flitsch
    ResearchOpen Access
    Nature Synthesis
    Volume: 3, P: 976-985

  • Biocatalytic methods to access thioesters, such as acyl-coenzyme A, from carboxylic acids are underdeveloped. Now, it is shown that the adenylation domain of a carboxylic acid reductase enzyme can be exploited as a promiscuous thioester synthetase and combination with acyltransferases facilitates the synthesis of amides and peptide labelling.

    • Christian Schnepel
    • Laura Rodríguez Pérez
    • Sabine L. Flitsch
    Research
    Nature Catalysis
    Volume: 6, P: 89-99

  • A biocatalytic enzyme originating from bacteria, EneIRED, facilitates amine-activated conjugate alkene reduction followed by reductive amination, efficiently preparing chiral amine diastereomers, which are commonly used in pharmaceuticals and agrochemicals. 

    • Thomas W. Thorpe
    • James R. Marshall
    • Nicholas J. Turner
    Research
    Nature
    Volume: 604, P: 86-91