In this study the authors demonstrate that the secretin/secretin receptor axis plays a regulatory role in biliary proliferation and liver fibrosis through differential changes in the senescence of cholangiocytes and hepatic stellate cells in a mouse model of primary sclerosing cholangitis. Targeting senescent cholangiocytes by modulation of the secretin/secretin receptor axis may provide a key therapeutic approach in the treatment of cholestatic liver diseases.
- Tianhao Zhou
- Nan Wu
- Gianfranco Alpini
