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Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

Nuclear deformation and mechano-signalling are regulated by the coupling of vimentin cytoskeleton to the extracellular matrix through fibrillar adhesions, modulating the timescale of mechanotransduction on force removal.

Amy E. M. Beedle
Vivek Sharma
Pere Roca-Cusachs
ResearchOpen Access29 Apr 2026
Nature Materials

P: 1-12

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Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

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