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Showing 1–3 of 3 results
Advanced filters: Author: Anup Aggarwal Clear advanced filters

  • Molecular glue degraders (MGD) offer a way to target undruggable proteins, but their discovery is challenging. Here, the authors develop a high-throughput proteomics platform for MGD drug discovery, revealing a much larger cereblon neosubstrate space than initially thought.

    • Martin Steger
    • Gisele Nishiguchi
    • Zoran Rankovic
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.

    • Geetika Singh
    • Cristina D. Guibao
    • Tudor Moldoveanu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15