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Showing 1–3 of 3 results
Advanced filters: Author: Anuradha Jagadeesan Clear advanced filters

  • Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

    • David W Clark
    • Yukinori Okada
    • James F Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Reconstructing the genome of an ancestor: 788 Icelanders are descended from a man who arrived there in 1802. 38% of his African mother’s genome has now been reconstructed from their pedigree and the genomes and genotypes of current Icelanders up to 8 generations later.

    • Anuradha Jagadeesan
    • Ellen D. Gunnarsdóttir
    • Agnar Helgason
    Research
    Nature Genetics
    Volume: 50, P: 199-205

  • Agnar Helgason and colleagues report the point mutation rate for the male-specific euchromatic sequence of the Y chromosome based on 753 Icelandic males. They find that the non-recombining portions of the Y chromosome mutate at a faster rate than palindromic regions, suggesting that gene conversion acts to correct mutations in palindromic sequences.

    • Agnar Helgason
    • Axel W Einarsson
    • Kári Stefánsson
    Research
    Nature Genetics
    Volume: 47, P: 453-457