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Showing 1–3 of 3 results
Advanced filters: Author: Anushree Gulvady Clear advanced filters

  • TGFβ signalling is reported to regulate hormone-responsive mammary epithelial progenitors that are associated with breast cancer risk. Here, the authors find that short-term TGFBR1 inhibition prevents tumour formation in rat breast cancer models and identify a TGFBR1 inhibition-responsive sub-population of mammary epithelial cells, which is associated with human breast cancer risk.

    • Maša Alečković
    • Simona Cristea
    • Kornelia Polyak
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Effective combination therapies to improve the efficacy of BET inhibitors are currently under investigation. Here, the authors examine palbociclib and paclitaxel as two promising candidates for combination therapies with BET inhibition in breast cancer and investigate the dynamics of resistance to these combinations through DNA barcoding and mathematical modelling.

    • Jennifer Y. Ge
    • Shaokun Shu
    • Kornelia Polyak
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17