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Advanced filters: Author: Anya Tsalenko Clear advanced filters

PeakDecoder enables machine learning-based metabolite annotation and accurate profiling in multidimensional mass spectrometry measurements

Alternative algorithms exploiting advantages of multidimensional mass spectrometry in untargeted metabolomics are needed. Here, the authors develop and demonstrate PeakDecoder for confident and accurate metabolite profiling in 116 microbial sample runs and using a library built from 64 standards.

Aivett Bilbao
Nathalie Munoz
Kristin E. Burnum-Johnson
ResearchOpen Access28 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

Improved efficiency of CRISPR/Cas editing with chemically modified synthetic sgRNAs.

Ayal Hendel
Rasmus O Bak
Matthew H Porteus
Research01 Sept 2015
Nature Biotechnology

Volume: 33, P: 985-989
Characterization of missing human genome sequences and copy-number polymorphic insertions

Paired-end sequencing of human genomic DNA reveals at least 2.8 Mb of new sequence at 720 distinct loci. Complete sequencing of 1.67 Mb at 192 loci reveals extensive copy-number variation and provides a resource for genotyping these 'missing' sequences.

Jeffrey M Kidd
Nick Sampas
Evan E Eichler
Research18 Apr 2010
Nature Methods

Volume: 7, P: 365-371

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