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Showing 1–6 of 6 results
Advanced filters: Author: Anya V. Grozhik Clear advanced filters

  • N1-methyladenosine (m1A) was recently reported as a new mRNA modification but its prevalence has been controversial. Here the authors showed that m1A, if present in mRNA, is at very low stoichiometry, with the notable exception of MT-ND5. Further, they show that the previously reported enrichment of m1A near the start of transcripts are false-positive identifications due to cross-reactivity of the commonly used m1A antibody with mRNA caps.

    • Anya V. Grozhik
    • Anthony O. Olarerin-George
    • Samie R. Jaffrey
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Fat mass and obesity-associated protein (FTO) preferentially demethylates m6Am, a modified adenosine that, when present at the 5′ end of certain mRNAs, positively influences mRNA stability by preventing DCP2-mediated decapping.

    • Jan Mauer
    • Xiaobing Luo
    • Samie R. Jaffrey
    Research
    Nature
    Volume: 541, P: 371-375

  • N6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.

    • Lijuan Kan
    • Anya V. Grozhik
    • Eric C. Lai
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • The presence of N1 methyl groups on adenine bases was thought to be widespread in messenger RNAs. It now seems that these modifications are much less prevalent, and occur on mRNAs that structurally mimic transfer RNA. See Letter p.251

    • Anya V. Grozhik
    • Samie R. Jaffrey
    News & Views
    Nature
    Volume: 551, P: 174-176