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Showing 1–4 of 4 results
Advanced filters: Author: Aoisha Hoyle Clear advanced filters

  • The prevalence of centrosome amplification (CA) and the genomic landscape of chromosomal instability in high-grade serous ovarian carcinoma (HGSOC) remain to be explored. Here the authors suggest CA as a potential driver of tumour evolution and a biomarker for treatment response in HGSOC.

    • Carolin M. Sauer
    • James A. Hall
    • James D. Brenton
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • The authors identify copy number signatures from shallow whole-genome sequencing of high-grade serous ovarian cancer (HGSOC) cases. HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in genomic aberration.

    • Geoff Macintyre
    • Teodora E. Goranova
    • James D. Brenton
    Research
    Nature Genetics
    Volume: 50, P: 1262-1270

  • The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibroblast and identify CLIC3 as a driver of cancer progression.

    • Juan R. Hernandez-Fernaud
    • Elena Ruengeler
    • Sara Zanivan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Mannose reduces the growth of tumour cells by impairing the metabolism of glucose, and enhances cell death when used in combination with conventional chemotherapy.

    • Pablo Sierra Gonzalez
    • James O’Prey
    • Kevin M. Ryan
    Research
    Nature
    Volume: 563, P: 719-723