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Showing 1–4 of 4 results

Advanced filters: Author: Apostolos Polykratis Clear advanced filters

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Necroptosis drives arthritis. Polykratis et al. show that the deubiquitinating enzyme A20 inhibits inflammasome-dependent arthritis development by regulating macrophage necroptosis and this function depends on its ZnF7 ubiquitin binding domain.

Apostolos Polykratis
Arne Martens
Manolis Pasparakis
Research13 May 2019
Nature Cell Biology

Volume: 21, P: 731-742
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

RIPK1 is shown to have a crucial role—independent of its known kinase function—in suppressing epithelial cell apoptosis and necroptosis in mice, thereby regulating homeostasis and preventing inflammation in barrier tissues.

Marius Dannappel
Katerina Vlantis
Manolis Pasparakis
Research17 Aug 2014
Nature

Volume: 513, P: 90-94
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

The enzyme RIPK1 functions through its RHIM domain to prevent ZBP1-mediated activation of RIPK3–MLKL-dependent necroptosis, thus preventing perinatal lethality and skin inflammation in adult mice.

Juan Lin
Snehlata Kumari
Manolis Pasparakis
Research07 Nov 2016
Nature

Volume: 540, P: 124-128
Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE^−/− mice

Takashi Imai
Trieu-My Van
Apostolos Polykratis
ResearchOpen Access22 Jul 2022
Scientific Reports

Volume: 12, P: 1-12