Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–10 of 10 results
Advanced filters: Author: Appu K. Singh Clear advanced filters

  • This report describes a nanobody targeting glycine receptor mGlyR that inhibits its ability to regulate G protein signaling and produces anti-depressant effects in mice providing an immunotherapy approach to potentially treat depression.

    • Thibaut Laboute
    • Stefano Zucca
    • Kirill A. Martemyanov
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • Transient receptor potential (TRP) channels are ubiquitous occurring cation-selective sensory ion channels that respond to various stimuli. Here the authors characterize crTRP1 from the alga Chlamydomonas reinhardtii, present its 3.5 Å cryo-EM structure and show that crTRP1 opens in response to increased temperature and is positively regulated by the membrane lipid PIP2.

    • Luke L. McGoldrick
    • Appu K. Singh
    • Alexander I. Sobolevsky
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • The X-ray crystal structure of rat transient receptor potential channel TRPV6 at 3.25 Å resolution is reported, providing new insights into its assembly and calcium-selective permeation.

    • Kei Saotome
    • Appu K. Singh
    • Alexander I. Sobolevsky
    Research
    Nature
    Volume: 534, P: 506-511

  • The transient receptor potential channel TRPV6 mediates calcium uptake in epithelia and its expression is increased in several cancer types. Here, authors present structures of TRPV6 bound to 2-APB, a TRPV6 inhibitor, and show that 2-APB induces TRPV6 channel closure by modulating protein–lipid interactions.

    • Appu K. Singh
    • Kei Saotome
    • Alexander I. Sobolevsky
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The cryo-electron microscopy structure of the calcium channel TRPV6 in its open and closed states demonstrates a novel gating mechanism involving an alanine hinge.

    • Luke L. McGoldrick
    • Appu K. Singh
    • Alexander I. Sobolevsky
    Research
    Nature
    Volume: 553, P: 233-237

  • Cryo-EM structures of mouse TRPV3 in open, closed and intermediate states, obtained by incubation of the protein samples at different temperatures immediately prior to freezing, offer insight into conformational changes induced by heat in TRPV3.

    • Appu K. Singh
    • Luke L. McGoldrick
    • Alexander I. Sobolevsky
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 994-998