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Showing 1–6 of 6 results
Advanced filters: Author: Apratim Mitra Clear advanced filters

  • The authors took a multimodal approach to characterize the differential transcriptome and epigenetic landscape between distinct regions of the embryonic mouse forebrain, revealing many unexplored presumptive promoter-enhancer interactions.

    • Christopher T. Rhodes
    • Joyce J. Thompson
    • Timothy J. Petros
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • KRAB-zinc finger proteins repress retrotransposons and rapidly evolve in mammals. Here, the authors show that ERV insertions drive the emergence and diversification of new KZFP genes in mice, revealing a co-evolutionary mechanism between retroviruses and host repressors.

    • Melania Bruno
    • Sharaf M. Farhana
    • Todd S. Macfarlan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Multimodal spatiotemporal transcriptomic resolution of palatal osteogenesis identifies previously unreported enriched genes in developing palate, paving the way toward viable diagnostic and therapeutic targets for cleft palate disorders.

    • Jeremie Oliver Piña
    • Resmi Raju
    • Rena N. D’Souza
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The authors show that the transcription factors NANOG and GATA6 co-bind the same enhancers in common progenitors before divergent epiblast and primitive endoderm lineages emerge. This may help maintain plasticity at early stages and facilitate bifurcation into distinct lineages

    • Joyce J. Thompson
    • Daniel J. Lee
    • Pedro P. Rocha
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Genetic manipulation of the Sox2 locus in mice shows that gene activation by distal enhancers does not require CTCF-mediated loops and can occur across ectopic CTCF-mediated boundaries. The ability to bypass CTCF boundaries varies with their insulation strength and the tissue-specific enhancers responsible for activation.

    • Shreeta Chakraborty
    • Nina Kopitchinski
    • Pedro P. Rocha
    Research
    Nature Genetics
    Volume: 55, P: 280-290

  • Low-grade chronic inflammation is linked to obesity-driven insulin resistance. Transglutaminases 2-expressing macrophages are increased in obesity and modulate adipose tissue inflammation, growth and insulin sensitivity in diet-induced obese mice.

    • Diana M. Elizondo
    • Tushar P. Patel
    • Jack A. Yanovski
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-14