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Showing 1–6 of 6 results
Advanced filters: Author: April Goehring Clear advanced filters

  • LeuT, a bacterial homologue of eukaryotic biogenic amine transporters (BATs), is engineered to harbour human BAT-like pharmacology by the mutation of key residues around the primary binding pocket; this mutant is able to bind several classes of antidepressant drug with high affinity, helping to define their common mechanisms of action.

    • Hui Wang
    • April Goehring
    • Eric Gouaux
    Research
    Nature
    Volume: 503, P: 141-145

  • Intraspecies response to climate change is expected to align with genetic affinity. Using the American pika as a case study suggests that divisions of species distributions best explain intraspecific heterogeneity in climate relationships.

    • Adam B. Smith
    • Erik A. Beever
    • Leah Yandow
    Research
    Nature Climate Change
    Volume: 9, P: 787-794

  • Structural studies of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction channel complex of Caenorhabditis elegans reveal the subunit composition and the roles of protein–membrane interactions in the conversion of mechanical force to ion channel activity.

    • Hanbin Jeong
    • Sarah Clark
    • Eric Gouaux
    ResearchOpen Access
    Nature
    Volume: 610, P: 796-803

  • X-ray crystal structures are presented of the N-methyl-d-aspartate (NMDA) receptor, a calcium-permeable ion channel that opens upon binding of glutamate and glycine; glutamate is a key excitatory neurotransmitter and enhanced structural insight of this receptor may aid development of therapeutic small molecules.

    • Chia-Hsueh Lee
    • Wei Lü
    • Eric Gouaux
    Research
    Nature
    Volume: 511, P: 191-197

  • The authors provide a detailed protocol for the isolation of four membrane protein complexes (transmembrane channel-like proteins 1 and 2, lipid transfer protein and ‘Protein S’) from transgenic C. elegans.

    • Sarah Clark
    • Hanbin Jeong
    • Eric Gouaux
    Protocols
    Nature Protocols
    Volume: 18, P: 2699-2716