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Showing 1–7 of 7 results
Advanced filters: Author: April Pawluk Clear advanced filters

  • Using cryo-electron microscopy, the structural mechanism by which non-coding bridge RNA confers target and donor DNA specificity to IS110 recombinases for programmable DNA recombination is explored.

    • Masahiro Hiraizumi
    • Nicholas T. Perry
    • Hiroshi Nishimasu
    ResearchOpen Access
    Nature
    Volume: 630, P: 994-1002

  • A bispecific non-coding RNA expressed by the IS110 family of mobile genetic elements forms the basis of a programmable genome-editing system that enables the insertion, excision or inversion of specific target DNA sequences.

    • Matthew G. Durrant
    • Nicholas T. Perry
    • Patrick D. Hsu
    ResearchOpen Access
    Nature
    Volume: 630, P: 984-993

  • A computational system termed MetaWIBELE (workflow to identify novel bioactive elements in the microbiome) is used to identify microbial gene products that are potentially bioactive and have a functional role in the pathogenesis of inflammatory bowel disease.

    • Yancong Zhang
    • Amrisha Bhosle
    • Eric A. Franzosa
    Research
    Nature
    Volume: 606, P: 754-760

  • CRISPR–Cas adaptive immune systems are widespread in prokaryotes. In this Progress article, Maxwell and colleagues highlight how phages and other mobile genetic elements inactivate CRISPR–Cas systems using anti-CRISPR proteins and outline evolutionary and biotechnological implications of anti-CRISPR protein activity.

    • April Pawluk
    • Alan R. Davidson
    • Karen L. Maxwell
    Reviews
    Nature Reviews Microbiology
    Volume: 16, P: 12-17