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Showing 1–2 of 2 results
Advanced filters: Author: Aranit Harizaj Clear advanced filters

  • Nanoparticle-mediated photoporation is used to temporarily permeabilize cell membranes for intracellular delivery of macromolecules, but cell exposure to nanoparticles might cause cellular damage and hamper application of the technique to therapeutic cell engineering. Here the authors show that, under photothermal heating, nanofibre-embedded iron oxide nanoparticles can be used to deliver effector macromolecules to different types of cells, in a contactless manner, with no cellular toxicity or diminished therapeutic potency.

    • Ranhua Xiong
    • Dawei Hua
    • Kevin Braeckmans
    Research
    Nature Nanotechnology
    Volume: 16, P: 1281-1291

  • Vitreous opacities, which are collagen aggregates that form in the eye and cause vision impairment (eye floaters), are currently treated with invasive surgical intervention or high-energy laser photoablation. In this paper, the authors show that exposing gold nanoparticles or indocyanine green to low-energy laser pulses generates vapour nanobubbles that can disrupt collagen aggregates in the eyes of rabbit, suggesting a milder strategy for the treatment of eye floaters.

    • Félix Sauvage
    • Van Phuc Nguyen
    • Stefaan C. De Smedt
    Research
    Nature Nanotechnology
    Volume: 17, P: 552-559