UCP1 is involved in regulating thermogenesis, and the Ucp1-Cre mouse line has been widely used for studying brown fat. Here they show that this mouse line carries an extra copy of the Ucp1 gene and displays unexpected changes in fat tissue function. Researchers should be cautious when interpreting studies using this model.
- Manasi Suchit Halurkar
- Oto Inoue
- Joan Sanchez-Gurmaches
