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Showing 1–10 of 10 results
Advanced filters: Author: Ardan Patwardhan Clear advanced filters

  • How can structural biology help us understand and combat SARS-CoV-2? Researchers in the field share their experiences and opinions and point to the challenges that lie ahead.

    • Montserrat Bárcena
    • Christopher O. Barnes
    • Qiang Zhou
    Special Features
    Nature Structural & Molecular Biology
    Volume: 28, P: 2-7

  • Bioimaging data have significant potential for reuse, but unlocking this potential requires systematic archiving of data and metadata in public databases. We propose draft metadata guidelines to begin addressing the needs of diverse communities within light and electron microscopy. We hope this publication and the proposed Recommended Metadata for Biological Images (REMBI) will stimulate discussions about their implementation and future extension.

    • Ugis Sarkans
    • Wah Chiu
    • Alvis Brazma
    Comments & Opinion
    Nature Methods
    Volume: 18, P: 1418-1422

  • This report describes the outcomes of the Data Management Challenges in 3D Electron Microscopy workshop. Key topics discussed include data models, validation and raw-data archiving. The meeting participants agreed that the EMDataBank should take the lead in addressing these issues, and concrete action points were agreed upon that will have a substantial impact on the accessibility of three-dimensional EM data in biology and medicine.

    • Ardan Patwardhan
    • José-Maria Carazo
    • Gerard J Kleywegt
    Comments & OpinionOpen Access
    Nature Structural & Molecular Biology
    Volume: 19, P: 1203-1207

  • We report the outcomes of the discussion initiated at the workshop entitled A 3D Cellular Context for the Macromolecular World and propose how data from emerging three-dimensional (3D) cellular imaging techniques—such as electron tomography, 3D scanning electron microscopy and soft X-ray tomography—should be archived, curated, validated and disseminated, to enable their interpretation and reuse by the biomedical community.

    • Ardan Patwardhan
    • Alun Ashton
    • Gerard J Kleywegt
    Comments & OpinionOpen Access
    Nature Structural & Molecular Biology
    Volume: 21, P: 841-845

  • A multi-laboratory study in the form of a community challenge assesses the quality of models that can be produced from cryo-EM maps using different software tools, the reproducibility of models generated by different users and the performance of metrics used for model validation.

    • Catherine L. Lawson
    • Andriy Kryshtafovych
    • Wah Chiu
    ResearchOpen Access
    Nature Methods
    Volume: 18, P: 156-164

  • Volume electron microscopy (vEM) is a group of techniques that reveal the 3D ultrastructure of cells and tissues through continuous depths of at least 1 micrometer. A burgeoning grassroots community effort is fast building the profile and revealing the impact of vEM technology in the life sciences and clinical research.

    • Lucy M. Collinson
    • Carles Bosch
    • Paul Verkade
    Comments & Opinion
    Nature Methods
    Volume: 20, P: 777-782

  • Public data archives are the backbone of modern biological research. Biomolecular archives are well established, but bioimaging resources lag behind them. The technology required for imaging archives is now available, thus enabling the creation of the first public bioimage datasets. We present the rationale for the construction of bioimage archives and their associated databases to underpin the next revolution in bioinformatics discovery.

    • Jan Ellenberg
    • Jason R. Swedlow
    • Ewan Birney
    Comments & OpinionOpen Access
    Nature Methods
    Volume: 15, P: 849-854