Patients with refractory ulcerative colitis often undergo ileal pouch anal anastomosis forming an ileal pouch. Here the authors use a single-cell genomics approach to show that ileal pouches from ulcerative colitis patients feature a unique type of enterocytes which express colonocyte-specific and inflammatory genes while also retaining expression of ileal marker genes.
- Yu Zhao
- Ran Zhou
- Sebastian Pott
