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Showing 1–8 of 8 results
Advanced filters: Author: Ari Molofsky Clear advanced filters

  • Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local immune response and lead to beneficial scar tissue formation.

    • Nathan A. Ewing-Crystal
    • Nicholas M. Mroz
    • Ari B. Molofsky
    ResearchOpen Access
    Nature
    Volume: 646, P: 934-944

  • Several studies from 2019 have highlighted emerging routes of communication between tissue-resident immune cells and local neurons, stromal cells, endothelial cells and epithelial cells to exert effects beyond the local tissue.

    • Ari B. Molofsky
    • Richard M. Locksley
    News & Views
    Nature Reviews Immunology
    Volume: 20, P: 93-94

  • Locksley et al. show tissue-specific imprinting dictates the activating receptors ILC2s express, even in germ-free mice. Skin ILC2s are preferentially activated by IL-18, and IL-18 contributes to inflammation in a mouse model of atopic dermatitis.

    • Roberto R. Ricardo-Gonzalez
    • Steven J. Van Dyken
    • Richard M. Locksley
    Research
    Nature Immunology
    Volume: 19, P: 1093-1099

  • Type 2 responses can be elicited by ILC2s and TH2 cells. Locksley and colleagues show that the epithelium-derived cytokines IL-25, IL-33 and TSLP are required for full effector activation of poised ILC2 and primed TH2 cell populations.

    • Steven J Van Dyken
    • Jesse C Nussbaum
    • Richard M Locksley
    Research
    Nature Immunology
    Volume: 17, P: 1381-1387

  • Eosinophil recruitment to the lung and intestine is regulated by type-2-innate-lymphoid-cell-derived IL-5 and IL-13; IL-5 is shown to be induced by the neuropeptide vasoactive intestinal peptide, which is known to coordinate pancreatic secretion with smooth muscle relaxation in response to feeding.

    • Jesse C. Nussbaum
    • Steven J. Van Dyken
    • Richard M. Locksley
    Research
    Nature
    Volume: 502, P: 245-248

  • Good–bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.

    • Carole Escartin
    • Elena Galea
    • Alexei Verkhratsky
    Reviews
    Nature Neuroscience
    Volume: 24, P: 312-325