Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Ariana Bratt Clear advanced filters

  • VCPIP1 is a deubiquitylase that binds the essential protein VCP/p97. Here, the authors present cryo-EM structures of VCPIP1 bound to VCP and the VCP-VCPIP1-p47 ternary complex along with biochemical and cellular data highlighting the functional importance of VCPIP1 domains in Golgi maintenance.

    • Binita Shah
    • Moritz Hunkeler
    • Sara J. Buhrlage
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • A genome-wide association study for lung cancer finds that genetic sequences in the nicotinic acetylcholine receptor subunit gene cluster contribute susceptibility. Interestingly, this susceptibility is not related to smoking status or frequency, and seems to come from a change in an amino acid in the receptor itself.

    • Rayjean J. Hung
    • James D. McKay
    • Paul Brennan
    Research
    Nature
    Volume: 452, P: 633-637

  • Deubiquitinases (DUBs) are key signaling enzymes, many of which lack selective inhibitors. Chan et al. pair a DUB-focused covalent library to mass spectrometry activity-based protein profiling, leading to selective hits against 23 endogenous DUBs and a first-in-class VCPIP1 probe with nanomolar potency.

    • Wai Cheung Chan
    • Xiaoxi Liu
    • Sara J. Buhrlage
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13