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Showing 1–9 of 9 results
Advanced filters: Author: Ariel A. Leonard Clear advanced filters

  • Batch effects hinder multi-sample single-cell data analyses. Here, authors present STACAS, a scalable single-cell RNA-seq data integration tool that uses prior cell type knowledge to preserve biological variability, demonstrating robustness to noisy input cell type labels.

    • Massimo Andreatta
    • Léonard Hérault
    • Santiago J. Carmona
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Adoptive cell therapies (ACT) hold promise for cancer immunotherapy, but optimization is still an ongoing process. Here the authors report CD4-targeted, nanoparticle-based artificial antigen-presenting cells that expand CD4+ T cells capable of lysing tumor cell lysis in vitro, and CD8+ T cells showing antitumor activity in a mouse melanoma model.

    • Ariel Isser
    • Aliyah B. Silver
    • Jonathan P. Schneck
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Lead trihalide perovskites are notable for their excellent optoelectronic properties and uncommon phase behavior. Here, Kirschner et al. show that cesium lead bromide nanocrystals experience a reversible orthorhombic-to-cubic phase transition at moderate excitation fluences and become amorphous at higher fluences.

    • Matthew S. Kirschner
    • Benjamin T. Diroll
    • Richard D. Schaller
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

    • Russell L. McLaughlin
    • Dick Schijven
    • Michael C. O’Donovan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis.

    • Michael A. Skinnider
    • Jordan W. Squair
    • Grégoire Courtine
    Research
    Nature Biotechnology
    Volume: 39, P: 30-34

  • Defect engineering and doping of semiconductors by ion irradiation are essential in large-scale integration of electronic devices. Here, intense ion pulses from a laser-accelerator, with flux levels up to 1022 ions cm-2 s-1, are used to induce and optimize silicon color centers and photon emitters in the telecom band.

    • Walid Redjem
    • Ariel J. Amsellem
    • Thomas Schenkel
    ResearchOpen Access
    Communications Materials
    Volume: 4, P: 1-10

  • The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

    • Gary A Churchill
    • David C Airey
    • Fei Zou
    Comments & Opinion
    Nature Genetics
    Volume: 36, P: 1133-1137