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Showing 1–3 of 3 results
Advanced filters: Author: Ariel M. Ley Clear advanced filters

  • Vijayanand and colleagues show highly suppressive CD4+CTLA-4+PD-1+ follicular regulatory T (TFR) cells reside within tumor microenvironments. Depleting TFR cells or blocking their activity with CTLA-4-depleting antibodies before anti-PD-1 checkpoint blockade therapy improved the efficacy of anti-PD-1 treatment in mouse tumor models and was also associated with better survival outcomes in a large cohort of patients with melanoma.

    • Simon Eschweiler
    • James Clarke
    • Pandurangan Vijayanand
    Research
    Nature Immunology
    Volume: 22, P: 1052-1063

  • Sanz and colleagues examine B cell subsets in a cohort of patients with COVID-19. Severely ill patients have higher frequencies of activated extrafollicular T-bet+ B cells that form antibody-secreting cells, the majority of which express germline sequences and are reminiscent of antibody responses observed in patients with systemic lupus erythematosus during flares.

    • Matthew C. Woodruff
    • Richard P. Ramonell
    • Ignacio Sanz
    Research
    Nature Immunology
    Volume: 21, P: 1506-1516