This study identifies regulators of the RNA sensor RIG-I. Diverse processes, including the unfolded protein response, Wnt signalling and RNA metabolism, modulate this pathway. The splicing regulator KHSRP is identified as a negative regulator of RIG-I that affects influenza replication in vivo.
- Stephen Soonthornvacharin
- Ariel Rodriguez-Frandsen
- Sumit K. Chanda
