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Cellular interactions within the immune microenvironment underpins resistance to cell cycle inhibition in breast cancers

The CDK4/6 inhibitor ribociclib holds promise in cancer therapy but how cell cycle inhibitory drugs affect the anti-tumor immune response remains a question. Here authors show that poor response of early-stage estrogen receptor positive breast cancers to ribociclib is caused by changes in the immune cell composition and cancer-cell-immune-cell communication in the tumors rather than intrinsic cancer cell resistance to cell cycle inhibition.

Jason I. Griffiths
Patrick A. Cosgrove
Andrea H. Bild
ResearchOpen Access03 Mar 2025
Nature Communications

Volume: 16, P: 1-23
Divergent oncogenic signaling and immune microenvironment changes in low-grade serous ovarian cancer patients undergoing intraperitoneal chemotherapy

Isaac Bishara
Patrick A. Cosgrove
Thanh H. Dellinger
ResearchOpen Access14 Dec 2025
npj Precision Oncology

Volume: 10, P: 1-13
Cell facilitation promotes growth and survival under drug pressure in breast cancer

In cancer, interactions between treatment-sensitive and resistant cells can influence the effectiveness of therapies. Here, the authors use experimental and mathematical models to explore interactions between ER+ breast cancer cell lineages that are sensitive or resistant to CDK4/6 inhibition, revealing the role of facilitative growth.

Rena Emond
Jason I. Griffiths
Andrea H. Bild
ResearchOpen Access29 Jun 2023
Nature Communications

Volume: 14, P: 1-17
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer

High-grade serous ovarian cancer (HGSOC) is prone to developing resistance to treatment. Here, the authors use single-cell RNA-seq and an analysis of archetypes, and find that shifts in metabolism and proliferation are associated with the response to treatment and clonal heterogeneity in HGSOC.

Aritro Nath
Patrick A. Cosgrove
Andrea H. Bild
ResearchOpen Access24 May 2021
Nature Communications

Volume: 12, P: 1-16
Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

Aritro Nath
Christina Chan
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-13
Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Aritro Nath
Irene Li
Christina Chan
ResearchOpen Access01 Oct 2015
Scientific Reports

Volume: 5, P: 1-19
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

Michael P. Menden
Dennis Wang
Julio Saez-Rodriguez
ResearchOpen Access17 Jun 2019
Nature Communications

Volume: 10, P: 1-17

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Cellular interactions within the immune microenvironment underpins resistance to cell cycle inhibition in breast cancers

Divergent oncogenic signaling and immune microenvironment changes in low-grade serous ovarian cancer patients undergoing intraperitoneal chemotherapy

Cell facilitation promotes growth and survival under drug pressure in breast cancer

Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer

Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

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