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Advanced filters: Author: Arjun K. Aditham Clear advanced filters

Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways

In this work, high-throughput microfluidic assays reveal how allosteric substitutions that alter folding-and-binding pathways shape DNA specificity and selectivity landscapes in the human transcription factor MAX.

Renee Hastings
Arjun K. Aditham
Polly M. Fordyce
ResearchOpen Access14 Jan 2025
Nature Communications

Volume: 16, P: 1-17

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Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways

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