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Atomic-scale imaging and charge state manipulation of NV centers by scanning tunneling microscopy

Nitrogen-vacancy (NV) centers in diamond are among leading candidates for solid-state qubit implementation. Here, with scanning tunneling microscopy, the authors image and manipulate the charge-state of NV centers at the atomic-scale for the first time.

Arjun Raghavan
Seokjin Bae
Vidya Madhavan
ResearchOpen Access27 Jan 2026
Nature Communications

P: 1-7
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Hypertrophic cardiomyopathy (HCM) leads to hyper-contractility of the heart and is often caused by mutations in human β-cardiac myosin. Here authors show that four separate β-cardiac myosin mutations can modulate myosin activity by disrupting intramolecular interactions.

Arjun S. Adhikari
Darshan V. Trivedi
Kathleen M. Ruppel
ResearchOpen Access18 Jun 2019
Nature Communications

Volume: 10, P: 1-10
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

Vivek Swarup
Flora I. Hinz
Daniel H. Geschwind
Research03 Dec 2018
Nature Medicine

Volume: 25, P: 152-164
To do no harm — and the most good — with AI in health care

Drawing from real-life scenarios and insights shared at the RAISE (Responsible AI for Social and Ethical Healthcare) conference, we highlight the critical need for AI in health care (AIH) to primarily benefit patients and address current shortcomings in health care systems such as medical errors and access disparities.

Carey Beth Goldberg
Laura Adams
Jianfei Zhao
Comments & Opinion22 Feb 2024
Nature Medicine

Volume: 30, P: 623-627
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

A working model for β-cardiac myosin in the sequestered state and binding assays reveal interactions between the myosin head and tail that are disrupted by mutations associated with hypertrophic cardiomyopathy.

Suman Nag
Darshan V Trivedi
James A Spudich
Research08 May 2017
Nature Structural & Molecular Biology

Volume: 24, P: 525-533
An orthogonal DNA replication system in yeast

A stable replication system, based on a DNA polymerase that replicates cytoplasmic plasmids with unique terminal proteins, decouples plasmid gene replication from host genome replication, allowing for continuous targeted evolution in vivo.

Arjun Ravikumar
Adrian Arrieta
Chang C Liu
Research02 Feb 2014
Nature Chemical Biology

Volume: 10, P: 175-177
A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme

Deepanjan Paul
Ashis Narayan Sinha
Arijit Mukhopadhyay
ResearchOpen Access26 May 2017
Scientific Reports

Volume: 7, P: 1-12

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Atomic-scale imaging and charge state manipulation of NV centers by scanning tunneling microscopy

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

To do no harm — and the most good — with AI in health care

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

An orthogonal DNA replication system in yeast

A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme

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