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Showing 1–5 of 5 results
Advanced filters: Author: Armand Sprecher Clear advanced filters

  • During an ongoing Ebola virus outbreak, infection before onset of protective immunity from vaccination is a possible scenario. Here the authors show in non-human primates that vaccination shortly before treatment with a monoclonal antibody does not negatively affect effectiveness of the antibody therapy.

    • Robert W. Cross
    • Zachary A. Bornholdt
    • Thomas W. Geisbert
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Concern over Ebola becoming endemic in West Africa has appeared in the medical and lay media. Routes of transmission, rates of viral evolution, suitability of humans as hosts and rarity of spillover events make this very unlikely. Without evidence that endemic Ebola is likely, ending epidemics should remain the focus.

    • Armand Sprecher
    • Heinz Feldmann
    • Michel Van Herp
    Comments & Opinion
    Nature Microbiology
    Volume: 1, P: 1-2

  • The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a result, the WHO disease classification of EVD underwent major revision.

    • Jens H. Kuhn
    • Takuya Adachi
    • Zabulon Yoti
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 17, P: 261-263

  • Fatal Ebola virus disease is characterized by a high proportion of CD4+ and CD8+ T cells expressing the inhibitory molecules CTLA-4 and PD-1, correlating with high virus load; individuals who survive the infection exhibit lower expression of these inhibitory molecules and generate Ebola-specific CD8+ T cells, suggesting that dysregulation of the T cell response is a key component of Ebola virus disease pathophysiology.

    • Paula Ruibal
    • Lisa Oestereich
    • César Muñoz-Fontela
    Research
    Nature
    Volume: 533, P: 100-104