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Nature Metabolism (2)

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Advanced filters: Author: Armon Goshayeshi Clear advanced filters

Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing

During ageing, S-adenosylmethionine (SAM) is depleted from muscle stem cells (MuSCs) because of increased synthesis of the polyamine spermidine, leading to loss of heterochromatin and dysfunction of MuSCs. SAM restoration rescues the mouse MuSC defects.

Jengmin Kang
Daniel I. Benjamin
Thomas A. Rando
Research19 Jan 2024
Nature Metabolism

Volume: 6, P: 153-168
Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

Brett et al. demonstrate that voluntary exercise improves quiescent muscle stem cell (MuSC) function and regenerative capacity in old but not young mice through exercise-induced upregulation of Cyclin D1 and repression of TGF-β activity in quiescent MuSCs.

Jamie O. Brett
Marina Arjona
Thomas A. Rando
Research13 Apr 2020
Nature Metabolism

Volume: 2, P: 307-317

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Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing

Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

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