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Showing 1–17 of 17 results
Advanced filters: Author: Arnab Ray Chaudhuri Clear advanced filters

  • The characterization of light irradiation for intensified flow reactors extends beyond the determination of photon fluxes, requiring the precise determination of optical path lengths. Here the authors introduce a systematic workflow that integrates radiometry, ray-tracing simulations and actinometry to obtain these system parameters.

    • Stefan D. A. Zondag
    • Jasper H. A. Schuurmans
    • Timothy Noël
    Research
    Nature Chemical Engineering
    Volume: 1, P: 462-471

  • EXO1 performs multiple roles in DNA replication and DNA damage repair (DDR), but its role in DDR-deficient cancers remains unclear. Here, the authors find EXO1 loss as synthetic lethal with many DDR genes involved in various cancers, including genes from Fanconi Anaemia pathway, BRCA1-A complex, and spliceosome factor ZRSR2; such interactions represent potential clinical targets.

    • Marija Maric
    • Sandra Segura-Bayona
    • Simon J. Boulton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Protection of nascent DNA from degradation provides a mechanism that can promote synthetic viability and drug resistance in Brca-deficient cells without restoring homologous recombination at double-strand breaks.

    • Arnab Ray Chaudhuri
    • Elsa Callen
    • André Nussenzweig
    Research
    Nature
    Volume: 535, P: 382-387

  • The cytotoxic effects of topoisomerase I inhibitors such as camptothecin can be modulated by replication fork reversal, in a process that requires Poly(ADP-ribose) polymerase (PARP) activity. Here human RECQ1 helicase is shown to restore such regressed replication forks, whereas PARP1 activity restrains this RECQ1 function.

    • Matteo Berti
    • Arnab Ray Chaudhuri
    • Alessandro Vindigni
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 347-354

  • Topoisomerase 1 (Top1) inhibition is believed to mediate cellular toxicity by trapping Top1 on nicked DNA, leading to double-strand break formation during replication. New studies show that clinically relevant doses of Top1 poisons lead instead to extensive replication-fork reversal that is mediated by Poly(ADP-ribose) polymerases, limiting double-strand break formation.

    • Arnab Ray Chaudhuri
    • Yoshitami Hashimoto
    • Massimo Lopes
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 417-423

  • Unrestrained 53BP1 activity causes fusions of dysfunctional telomeres and embryonic lethality associated with misrepair of DNA double-strand breaks in BRCA1-deficient mice. However, the physiological role of 53BP1 remains unclear, because it presumably did not evolve to carry out these pathological functions. A new report proposes that 53BP1 activity prevents hyper-resection and thereby promotes error-free DNA repair while suppressing alternative mutagenic pathways.

    • Dali Zong
    • Arnab Ray Chaudhuri
    • André Nussenzweig
    News & Views
    Nature Structural & Molecular Biology
    Volume: 23, P: 699-701

  • Recent insights into the roles of poly(ADP-ribose) polymerase 1 (PARP1) in mediating various DNA repair pathways, stabilizing DNA replication and modulating chromatin structure are being exploited clinically for the treatment of DNA repair-deficient cancers.

    • Arnab Ray Chaudhuri
    • André Nussenzweig
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 610-621

  • The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.

    • Xia Ding
    • Arnab Ray Chaudhuri
    • Shyam K. Sharan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • BRCA2 is involved in both homologous recombination (HR) and the protection of stalled replication forks from degradation. Here the authors reveal how HR factors cooperate in fork remodeling, showing that BRCA2 supports RAD51 loading on the regressed arms of reversed replication forks to protect them from degradation.

    • Sofija Mijic
    • Ralph Zellweger
    • Massimo Lopes
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11