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Diagnosis, novel mechanisms of disease and promising agents

The results of various studies from 2010 have underlined the importance of the careful diagnostic assessment of GERD. Recent studies have also provided further evidence of the complex pathogenesis of GERD, and promising agents targeting the underlying factors in the pathogenesis of this condition are in the pipeline, especially for treatment-refractory GERD.

Arne Kandulski
Peter Malfertheiner
News & Views04 Feb 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 73-74
Gastroesophageal reflux disease—from reflux episodes to mucosal inflammation

Gastroesophageal reflux disease (GERD) is a chronic disorder that occurs when refluxate from the stomach comes into contact with the esophageal mucosa, typically causing symptoms such as heartburn and regurgitation. This Review focuses on the mucosal pathogenesis of GERD and describes new concepts in the role of mucosal inflammation in disease development in relation to the current model of GERD pathogenesis.

Arne Kandulski
Peter Malfertheiner
Reviews22 Nov 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 9, P: 15-22
Proton-pump inhibitors: understanding the complications and risks

Proton-pump inhibitors (PPIs) are widely used for gastric acid suppression in a number of gastric-acid-related diseases, including GERD. However, in recent years, increasing evidence of adverse events has been reported, raising concerns with clinicians and patients. This Review provides an update on the complications and risks of PPI use.

Peter Malfertheiner
Arne Kandulski
Marino Venerito
Reviews20 Sept 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 14, P: 697-710
Elevated long-to-very-long-chain ceramide ratio correlates with disease severity in inflammatory bowel disease and primary sclerosing cholangitis

Tanja Elger
Muriel Huss
Christa Buechler
ResearchOpen Access25 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Critical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre

Alexander Scheiter
Frederik Hierl
Kirsten Utpatel
ResearchOpen Access26 Dec 2022
British Journal of Cancer

Volume: 128, P: 1134-1147
Retrospective evaluation of early thrombosis in transjugular intrahepatic portosystemic polytetrafluoroethylene-coated shunts under 2-day postinterventional heparinization

Holger Goessmann
Verna Schuffenhauer
Niklas Verloh
ResearchOpen Access22 Jun 2022
Scientific Reports

Volume: 12, P: 1-11

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Diagnosis, novel mechanisms of disease and promising agents

Gastroesophageal reflux disease—from reflux episodes to mucosal inflammation

Proton-pump inhibitors: understanding the complications and risks

Elevated long-to-very-long-chain ceramide ratio correlates with disease severity in inflammatory bowel disease and primary sclerosing cholangitis

Critical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre

Retrospective evaluation of early thrombosis in transjugular intrahepatic portosystemic polytetrafluoroethylene-coated shunts under 2-day postinterventional heparinization

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