This paper shows that regulatory T (Treg) cells express the transcription factor IRF4, which is essential for the differentiation of TH2 effector cells. IRF4 depletion in Treg cells induces TH2-driven autoimmune disease, leading the authors to suggest that IRF4 directs a module within Treg cells that selectively suppresses TH2 responses.
- Ye Zheng
- Ashutosh Chaudhry
- Alexander Y. Rudensky