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Showing 1–10 of 10 results
Advanced filters: Author: Arnold Reynaldi Clear advanced filters

  • SARS-CoV-2 vaccines have been updated to include antigens from new variants. Here, the authors analyse data from published studies to investigate whether updating vaccines provides additional immunity to subsequent emerging strains compared to using original vaccines.

    • Deborah Cromer
    • Arnold Reynaldi
    • Miles P. Davenport
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • In this study, the authors perform a meta-analysis of COVID-19 vaccine effectiveness studies and compare observed protection against severe disease with model-based estimates of neutralising antibody titres. Their results show that SARS-CoV-2 antibody titres are predictive of protection against severe COVID-19 disease.

    • Deborah Cromer
    • Megan Steain
    • Miles P. Davenport
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • Wragg and colleagues use MHC class II tetramers and TCRβ sequencing to track clonal populations of spike-specific CD4+ cTFH cells from cohorts of convalescent individuals with coronavirus disease 2019 or SARS-CoV-2-vaccinated individuals over 15 months.

    • Kathleen M. Wragg
    • Wen Shi Lee
    • Jennifer A. Juno
    Research
    Nature Immunology
    Volume: 23, P: 768-780

  • Longitudinal analyses are needed to show how the immune response to Sars-Cov-2 infection changes over time. Here, the authors use multiple strategies to profile the change in immune cell responses from patients with convalescent COVID-19 over the course of ~5 months, showing that although neutralizing antibody responses drop off after ~4 months, B cell immune responses strengthen.

    • Adam K. Wheatley
    • Jennifer A. Juno
    • Stephen J. Kent
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • In a cohort of recovered patients with COVID-19, virus spike-specific antibodies were consistently elicited, but neutralizing activity was highly variable and inversely correlated with the proportion of CCR6+CXCR3− spike-specific circulating follicular helper T cells.

    • Jennifer A. Juno
    • Hyon-Xhi Tan
    • Adam K. Wheatley
    Research
    Nature Medicine
    Volume: 26, P: 1428-1434

  • Understanding of the role of T cells in SARS-CoV-2 infection is of great importance for the design of next-generation vaccines. In this Perspective, Davenport and colleagues discuss the challenges in determining a causal relationship between vaccine-induced T cell immunity and protection from COVID-19.

    • Stephen J. Kent
    • David S. Khoury
    • Miles P. Davenport
    Reviews
    Nature Reviews Immunology
    Volume: 22, P: 387-397

  • The duration of immunity to coronavirus disease 2019 (COVID-19) from prior infection and longer-term risk of reinfection are currently unclear. Cromer and colleagues discuss the immune control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the implications of this for the future control of the pandemic.

    • Deborah Cromer
    • Jennifer A. Juno
    • Miles P. Davenport
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 395-404

  • Are you new to virus research and trying to interpret the ever-expanding literature on immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)? Here, the authors compare the different assays and animal models used to measure immunity to SARS-CoV-2 infection and reconcile differences in apparent potency of antibodies assessed in different assays.

    • David S. Khoury
    • Adam K. Wheatley
    • Miles P. Davenport
    Reviews
    Nature Reviews Immunology
    Volume: 20, P: 727-738