This study is to investigate and systemically study the mechanical performance of supramolecular PEG hydrogels in comparison with those of the chemical hydrogels cross-linked by conventional PEG diacrylate (PEGDA). The supramolecular cross-links based on the host-guest complexation significantly enhance the energy dissipation, fatigue resistance, and stress-relaxation of supramolecular PEG hydrogels and protect cells from deleterious mechanical insults. This research provides valuable guidance on the design of prosthetic hydrogels for loading bearing implantations sites with surrounding mechanosensitive cells or tissues and critical insights on the translation of host-guest hydrogels to biomedical applications.
- Xiaoyu Chen
- Chaoqun Dong
- Liming Bian
