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Showing 1–2 of 2 results
Advanced filters: Author: Arunabh Athreya Clear advanced filters

  • The GABA transporters (GATs) enforce spatiotemporal control of the inhibitory neurotransmitter GABA at neural synapses. Nayak et al. report the structure of substrate-bound GAT1 in an ion-bound cytosol-facing conformation, providing mechanistic insights into GABA selection and reuptake.

    • Smruti Ranjan Nayak
    • Deepthi Joseph
    • Aravind Penmatsa
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1023-1032

  • Sushant Kumar et. al. report the 3.6 Å resolution crystal structure of NorC, a 14-transmembrane major facilitator superfamily member that is implicated in fluoroquinolone resistance in drug-resistant Staphylococcus aureus strains. The NorC structure was determined in complex with a single-domain camelid antibody that blocks access to the transporter and thus constitutes a new mode of inhibition.

    • Sushant Kumar
    • Arunabh Athreya
    • Aravind Penmatsa
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11