The authors previously developed a mouse model ABab-A2 transduced with complete human TCR gene loci and HLA-A*02:01, termed ABab-A2 mice. Here the authors introduce a complete HLA-I haplotype into ABab-A2 mice and make the ABab-I mice, which manifest higher peripheral CD8 counts, broader TCR repertoire and stronger epitope response compared to ABab-A2 mice.
- Arunraj Dhamodaran
- Xiaojing Chen
- Thomas Blankenstein
