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Showing 1–9 of 9 results
Advanced filters: Author: Aryeh Warmflash Clear advanced filters
  • Studying morphogen gradient formation and reception in mammalian development is challenging. Here, the authors show with human gastruloids that Nodal activity in live cells spreads via a relay mechanism with timing that is locally controlled by Lefty, which dictates mesoderm differentiation timing.

    • Lizhong Liu
    • Anastasiia Nemashkalo
    • Aryeh Warmflash
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12
  • Stem cell interactions involve biochemical and biophysical cues, but the transcriptional control of biophysical traits is unclear. This study identifies ETVs as regulators of adhesion in hPSCs and pancreatic progenitors, shaping lineage decisions.

    • Natalia M. Ziojła
    • Magdalena Socha
    • Malgorzata Borowiak
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21
  • This protocol describes how to differentiate and image human embryonic stem cells on micropatterned colonies to create radially organized domains of the germ layers mimicking embryonic gastrulation in vitro.

    • Alessia Deglincerti
    • Fred Etoc
    • Aryeh Warmflash
    Protocols
    Nature Protocols
    Volume: 11, P: 2223-2232
  • Pluripotent stem cells are being used to generate models of early embryogenesis that are promising for discovery and translational research. To be useful, these models require critical consideration of their level of efficiency and fidelity to natural embryos. Here we propose criteria with which to raise the standards of stem-cell-based embryo models of human embryogenesis.

    • Alfonso Martinez Arias
    • Nicolas Rivron
    • Aryeh Warmflash
    Comments & Opinion
    Nature Cell Biology
    Volume: 26, P: 1625-1628
  • The plasma membrane’s electrical potential is maintained by ion channels, though the impact of this potential on cell fate has not been clearly elucidated. Here they show that changes in membrane potential can affect calcium levels and mTOR in pluripotent stem cells, altering their transition from pluripotency to differentiation.

    • Emily Sempou
    • Valentyna Kostiuk
    • Mustafa K. Khokha
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17
  • This Review highlights the recent emergence of stem-cell-derived embryo models for the purpose of advancing our understanding of mammalian embryology as well as their potential uses in regenerative and reproductive medicine.

    • Jianping Fu
    • Aryeh Warmflash
    • Matthias P. Lutolf
    Reviews
    Nature Materials
    Volume: 20, P: 132-144