Cyclophosphamide is one of the most widely utilized chemotherapeutic and immunosuppressive agents in many combination chemotherapy regimens and autoimmune conditions. This Review highlights the chemistry, pharmacology, clinical toxic effects and current clinical applications of cyclophosphamide in cancer and autoimmune disorders. It also discusses the development of high-dose cyclophosphamide for blood and marrow transplantation and the treatment of autoimmune diseases.
- Ashkan Emadi
- Richard J. Jones
- Robert A. Brodsky
