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High-throughput methods leveraging robotics and computer vision for the development of therapeutic phage cocktails

In this work, authors present an automated, high-throughput platform that utilizes robotics and computer vision to enable creation of a therapeutic phage cocktail, LBP-EC01, effective against over 96% of tested Escherichia coli isolates from urinary tract infections.

Taylor J. R. Penke
Aeron Tynes Hammack
Paul Garofolo
ResearchOpen Access30 Jan 2026
Nature Communications

P: 1-13
Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb development.

Rory Henderson
Brian E. Watts
S. Munir Alam
ResearchOpen Access08 Feb 2019
Nature Communications

Volume: 10, P: 1-14
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

Here, the authors report that specific monoclonal antibodies isolated from vaccinated rhesus macaques can neutralize a subset of Tier 2 difficult-to-neutralize HIV-1 that express Env in an open conformation, suggesting that V3 loop-specific targeting can bias the estimation of vaccine-induced bnAbs.

Qifeng Han
Julia A. Jones
Kevin O. Saunders
ResearchOpen Access01 Jul 2019
Nature Communications

Volume: 10, P: 1-15
Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus

Infection of African green monkeys with simian immunodeficiency virus is a potential model for HIV vaccine development. Here, Zhang et al. catalogue the immunoglobulin loci present in the genome of these animals, and experimentally study their B-cell response to the viral envelope protein.

Ruijun Zhang
David R. Martinez
Sallie R. Permar
ResearchOpen Access06 Jul 2016
Nature Communications

Volume: 7, P: 1-11
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

The identification of antibodies targeting a conserved site of vulnerability in the Plasmodium falciparum circumsporozoite protein reveals opportunities for passive prevention of malaria in vulnerable individuals and provides insights for rational vaccine design.

Neville K Kisalu
Azza H Idris
Robert A Seder
Research19 Mar 2018
Nature Medicine

Volume: 24, P: 408-416
Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Neville K Kisalu
Azza H Idris
Robert A Seder
Amendments and Corrections14 Dec 2018
Nature Medicine

Volume: 25, P: 188-189
Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments

Ashley M Trama
Zoie E Holzknecht
William Parker
Research13 Feb 2012
Cellular & Molecular Immunology

Volume: 9, P: 163-174

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High-throughput methods leveraging robotics and computer vision for the development of therapeutic phage cocktails

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments

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